The Research Topic will include: - Growth-promoting activities of ACTH -Ěcute and chronic regulation of steroid secretion by ACTH, including effect of ACTH on circadian rythms of secretion. A particular attention will be given to how various kinases, phosphatases and cytoskeleton-associated proteins interact to ensure homeostasis and/or meet physiological demands. In this Research Topic, we will discuss the various mechanisms involved in ACTH action, from ACTH binding to its receptor to steroid secretion, as well as the pathological consequences of the disruption of specific components of the pathways. By stimulating adrenal corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and stress response.
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